Amlodipine
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Class of drug
- 3rd generation dihydropyridine calcium-channel blocker.
Action
- Blocks calcium channel function - particularly in the peripheral vasculature.
Indications
- Treatment of systemic hypertension
 in cats.
Routes of administration
- Oral: 5 mg, 10 mg tablets.
Dosage
Basic dose
Cats
- 0.625-1.25 mg/cat PO SID.
Normal
Metabolism
Physiological, variations
Pregnancy
- Avoid use during pregnancy.
Pathological variations
Cardiac insufficiency
- Do not use in presence of cardiogenic shock.
Renal insufficiency
- Appears to be safe even with concurrent renal failure.
Hepatic insufficiency
- Reduce dose if reduced hepatic function.
Contra-indications
- No adverse effects reported in cats at recommended dose rate.
Interactions
with other drugs
- Little information in cats.
- Hepatic metabolism may be impaired by other drugs eg cimetidine .
- Risk of hypotension if combined with other antihypertensive agents eg ACE inhibitors .
Publications
Refereed papers
- Elliott J, Barber PJ, Syme HM, Rawlings JM & Markwell PJ (2001) Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases. J Small Anim Pract. 42 (3), 122-129.
Other sources of information
- Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.
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FELIS GEN00695
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