Spironolactone Jump to... Uses Administration Pharmocokinetics Precautions Adverse Reactions Antidotes Preparations Sources Name Spironolactone. Class of drug Potassium-sparing diuretic. Description Chemical name 17-hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid-alpha-lactone. Uses Top Action Competitively inhibits aldosterone, thus preventing sodium reabsorption in the distal tubule. Also potentiates thiazide and loop diuretics. Indications Particularly useful in the treatment of edema associated with congestive heart failure (when hypokalemia may potentiate digoxin toxicity) and hepatic failure (when hypokalemia can precipitate hepatic encephalopathy ). Used in combination diuretic therapy (with thiazides and furosemide). Administration Top Routes of administration Orally. Dosage Basic dose Cats, dogs 2-4 mg/kg PO SID. Pharmocokinetics Top Normal Distribution 98% protein-bound. Metabolism Metabolized to active metabolite, canrenone. Precautions Top Contra-indications In patients with significant renal disease of hyperkalemia. Use with care In patients with renal or hepatic impairement. Interactions with other drugs ACE inhibitors, eg captopril, enalapril Hyperkalemia may result. NSAIDs Hyperkalemia may result. There is an increased risk of nephrotoxicity Potassium supplements Hyperkalemia may result. Digoxin May increase half-life of digoxin. The effect of digoxin may be enhanced. with diagnostic tests Electrolyte imbalances should be monitored. Adverse reactions Top Other reported reactions Spironolactone interferes with the synthesis of testosterone and may cause associated endocrine abnormalities. Sources Top Publications Other sources of information Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. Vetstream contributor(s) Dr Mark Rishniw DVM DipACVIM, VRT Box 34, Department of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA. Fax: 001-607-253 3317. Back to top © Copyright Vetstream FELIS GEN00262

Subscribers and trialists can view the additional links below and within theadjacent article. To trial our services click here: Congestive heart failure Digitoxin Digoxin Hepatic encephalopathy Hypertension Liver: chronic disease Liver: cirrhosis Potassium chloride gluconate Therapeutics: cardiovascular system Please click on the links below to view this months other FOC content: Amlodipine Feline primary hyperaldosteronism Potassium chloride gluconate

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