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Potassium chloride / gluconate
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Name
  • Potassium chloride/gluconate.


Class of drug
  • Electrolyte.
Uses Top

Indications
  • Treatment of hypokalemia .
Administration Top


Routes of administration
  • Injectable solution.
  • Oral powder, tablets and syrup.


Dosage

Basic dose
  • Intravenous doses must be titrated for each patient; dilute concentrated solutions prior to use.
  • Serum potassium <2 mmol/l: add 20 mEq to 250 ml 0.9% NaCl.
  • Serum potassium 2-2.5 mmol/l: add 15 mEq to 250 ml 0.9% NaCl.
  • Serum potassium 2.5-3 mmol/l: add 10 mEq to 250 ml 0.9% NaCl.
  • Serum potassium 3-3.5 mmol/l: add 7 mEq to 250 ml 0.9% NaCl.
  • Rate of IV infusion should not exceed 0.5 mmol/kg bodyweight/h.
    Cat
  • 2-6 mmol/cat/day.
    Dog
  • 0.2-0.5 mmol/kg PO TID or 1-3 g/dog PO SID.
Pharmocokinetics Top
Precautions Top


Use with care
Acid-base imbalances
  • As potassium is primarily an intracellular electrolyte, serum levels do not adequately reflect its total body store.
  • Acid-base imbalances may also mask the actual extent of any alterations in potassium levels.
    • Patients with systemic acidosis may appear to be hyperkalemic when in fact they may have a significantly low total body potassium content.
    • Conversely alkalosis may falsely indicate a low serum K Blood biochemistry: potassium.


Interactions

with other drugs
ACE inhibitors, eg captopril
  • Increase the risk of hyperkalemia developing.
    Potassium sparing diuretics, eg spironolactone
  • Increase the risk of hyperkalemia developing Spironolactone.
Adverse reactions Top

Other reported reactions
  • Gastrointestinal irritation (oral preparations).
Sources Top

Publications

Other sources of information
  • Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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