Griseofulvin
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Name
Class of drug
Action
- A fungistatic antibiotic produced by Penicillium spp.
- Acts on susceptible fungi by disrupting the mitotic spindle, thereby arresting cell division in metaphase.
Indications
- Griseofulvin is active against Trichophyton spp
 , Microsporum spp , and Epidermophyton spp .
Routes of administration
- Oral: 125 mg, 500 mg tablets; 7.5% w/w powder.
Dosage
Basic dose
Cats, dogs
Small mammals
- 25-30 mg/kg PO SID.
- Some texts recommend higher doses for cats and dogs (40-50 mg/kg SID).
- Duration of treatment is usually 3-4 weeks (can be up to 112 weeks).
Normal
Oral absorption
- To enhance absorption administer with 2.5-5 ml of corn oil or after a meal high in fat.
Physiological, variations
Pregnancy
 Do not use in pregnant animals.
Contra-indications
- If possible avoid use in pregnant animals.
- Griseofulvin is teratogenic in cats and may be a teratogen in other animals.
Use with care
Women of child bearing age should take care handling product.
- Personnel should wear gloves.
- Tumors have developed in laboratory animals given griseofulvin long-term.
Interactions
with other drugs
Warfarin-class anticoagulants
- Griseofulvin may decrease their activity.
Barbiturates
- May accelerate the metabolism of griseofulvin.
Other reported reactions
- Gastrointestinal (GI) distress.
- Hypersensitivity reactions.
- Decreased spermatogenesis.
- Hepatotoxicity.
- Leukopenia (cat).
Publications
Other sources of information
- Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA. ISBN: 0 9052 1452 8.
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