Clotrimazole
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Name
Class of drug
Description
Chemical name
- 1-[(2-chlorophenyl)diphenylmethyl]-1H-imidazole.
- 1-(o-chloro-alpha,alpha-diphenylbenzyl)imidazole.
Molecular formula
Physical properties
- Opaque liquid solution.
- Spray.
- Powder.
Storage requirements
Action
- Broad spectrum fungistatic.
- Inhibits cytochrome P450-dependent ergosterol synthesis.
Indications
- Pathogenic dermatophytes, yeasts
 and Aspergillus spp .
Routes of administration
- Topical: cream and solution.
Dosage
Basic dose
Dog, Cat
- Otic: instill 3-5 drops in ear BID.
- Topical: apply to affected area and massage in gently BID; if no improvement in 4 weeks re-evaluate therapy or diagnosis.
Bird
- Intratracheal - 2-3 ml of 1% solution nebulized for periods of 1 h SID, or topically.
Publications
Refereed papers
- Sawyer P R et al (1975) Clotrimazole - a review of its antifungal activity and therapeutic efficacy. Drugs 9 (6), 424-427.
Other sources of information
- Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.
Vetstream contributor(s)
- Rosanna Marsella, PO Box 100126, College of Veterinary Medicine, University of Florida, Gainsville, FL 32610-126, USA.
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