Acetyl salicylic acid (Aspirin )

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• Acetyl salicylic acid.

• Non-steroidal anti-inflammatory drug (NSAID).

• 2-(acetyloxy)benzoic acid.
• Salicylic acid acetate.

• C9H8O4.

• Tablets.

• In a cool, dry place.

• Non-steroidal anti-inflammatory drug which inhibits cyclooxygensase-1 enzyme thereby limiting prostaglandin production.
• NSAIDs have antipyretic, analgesic, anti-inflammatory and anti-platelet effects.

• Control of mild to moderate pain.
• Prevention of arterial thromboembolization.
• Rheumatoid arthritis.

• Oral: 75 mg, 300 mg tablets.

• Antipyretic/analgesic: 10 mg/kg PO BID.
• Anti-inflammatory: 10-25 mg/kg PO BID-TID.
• Rheumatoid arthritis: 42 mg/kg PO q3d.
   Some texts recommend a very low dose of 0.5 mg/kg PO SID to inhibit platelet cyclooxygenase (and therefore platelet function) without preventing the beneficial effects of prostacyclin production.

Cat

• 10-25 mg/kg PO SID; a suggested dosing schedule for chronic therapy (anti-inflammatory or anti-platelet disease) in an average sized cat, 1/4 of a 300 mg tablet PO on Monday, Wednesday and Friday.

• Most body tissues and transcellular fluids.
• Crosses blood-brain barrier slowly.

• Mostly liver but other tissues.

• Mainly excreted by kidneys.

• Use with care in animals less than 6 weeks old.

• Do not use.

• Use with care in aged animals.

• Do not use.

• Do not use, causes renal papillary necrosis.

• Do not use.

• Do not use if gastric or duodenal ulceration is suspected, in hemorrhagic syndromes or in cases of renal failure.
• Do not use with corticosteroids, methoxyflurane or other NSAIDs.

• Do not use with corticosteroids, methoxyflurane or other NSAIDs.
• In man there is an increased risk of convulsions if NSAIDs are administered with floroquinolones.
• NSAIDs may antagonize the hypotensive effects of anti-hypertensives, eg beta-blockers.
• Concomitant use of diuretics may increase the risk of nephrotoxicity.
• Do not mix with other substances in the same syringe.

• Vomiting, GI bleeding.
• Pyrexia.
• Metabolic acidosis.
• Depression.
• Coma, seizures.

• Adverse effects are dose-related and reflect the pathophysiological changes expected with reduced prostaglandin synthesis.
• Gastrointestinal irritation and ulceration (most common adverse effect).
• Blood dyscrasias (rare).
• Hepatotoxicity (rare).
• Renal papillary necrosis (renal failure) is the second most common adverse effect, particularly if hypotension, dehydration or other nephrotoxic drugs are present.

• Emptying the gut.
• Treat the acidosis.
• Alkalinize the urine with sodium bicarbonate.
• Supportive therapy.
• Cytoprotection from gastric ulceration is provided by misoprostal .

• Based on Small Animal Formulary. Tennant, Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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